Endocrine Abstracts

Introduction: The multimodal management of poorly differentiated thyroid carcinomas (PDTC) and anaplastic carcinomas (ATC) include surgical thyroidectomy, radioiodine treatment, and cytotoxic chemotherapy. Patients with distant metastases which do not respond to radiotherapy could be treated with new therapeutic possibilities like tyrosine kinase inhibitors. PPARγ or mutant P53 are also candidates to PDTC and ATC treatment. Somatostatin and its analogs, demonstrate antipr...

Introduction: Somatostatin analogues (SSAs) are used in the treatment of somatotropinomas. Actually, the use of these drugs in clinically non-functioning pituitary adenomas (NFPA) is raised. The aim of the study is to assess the effectiveness of SSA therapy in both groups.Materials and methods: 40 acromegalic patients and 22 patients with NFPA were treated with SSA for the total therapy duration up to 10 years. Hormonal profile, dynamics of tumour size c...

Introduction: Macroforms of prolactin (PRL), the most often macroprolactin (MaPRL), may be the cause of about 25% cases of laboratory diagnosed hyperprolactinaemia. Macroprolactin is usually quantified by polyethylene glycol precipitation, however, the cut-off value (that means the calculated recovery ratio of monomeric PRL) has not been precisely determined and has rather unsatisfactory diagnostic specificity. Therefore, it is suggested that the evaluation of hyperprolactinae...